We have yet to see clinical studies of chanca piedra in people with cognitive dysfunction. Foo LY. Protocol for callus culture of Phyllanthus amarus Schum and Thonn. In one human study that showed improvements in kidney stones, the daily dosage was 4.5 grams of powdered chanca piedra for 12 weeks (3). Leelarasamee, A., Trakulsomboon, S., Maunwongyathi, P., Somanabandhu, A., Pidetcha, P., Matrakool, B., Lebnak, T., Ridthimat, W., and Chandanayingyong, D. Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers. Int Braz J Urol 2018;44(4):758-64. It enlarged blood vessels and caused kidney damage in rats and mice [159, 160, 161]. What did you take to control the pain that was considered safe . Therefore, its best to avoid it while pregnant, trying to get pregnant, or breastfeeding. J Ethnopharmacol. According to studies in mice and rats, it blocks pain signals and swelling indirectly: by lowering inflammatory compounds that build up around nerves [93, 94, 95, 96, 85, 84, 97, 98, 99]. The nursing mother should take the lowest dose possible. Yet, one human study noted a slight increase in blood pressure in people taking chanca piedra. View abstract. Thyagarajan, S. P., Jayaram, S., Valliammai, T., Madanagopalan, N., Pal, V. G., and Jayaraman, K. Phyllanthus amarus and hepatitis B. Lancet 10-13-1990;336(8720):949-950. Scientific Research and Essays 2008;370-372. View abstract. (Taung-ze-phyu) on rabbit model. Gout flare-ups can occur when high levels of uric acid build up in the blood. This might increase the risk of blood pressure becoming too low. Duke JA, Vasquez R. Amazonian Ethnobotanical Dictionary. Generally, if you are pregnant, nursing, have any health condition or are taking any medications, it is recommended that you consult your health care professional before using herbs, including culinary herbs. Journal of Medicinal and Aromatic Plant Sciences 2003;25(3):743-745. 2014;9(4):515-7. McPartland JM. Kumar, K. B. and Kuttan, R. Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Cancer Detect.Prev. The term "Chanca Piedra" literally means "to break stone" which reflects its traditional use in treating kidney stones and gallstones. Chanca piedra is a tropical herb known as a traditional cure for potential kidney stones. In a clinical study of 30 children with viral diarrhea, chanca piedra (Phyllanthus niruri) improved symptoms such as stool consistency, fever, vomiting, stomach pain, loss of appetite, and dehydration. Its scientific Latin name is Phyllanthus niruri and it also goes by other names, including "gale of the wind" and "seed-under-leaf." Chanca Piedra has traditionally been used to break up or expel gallstones . It should also not be taken while breastfeeding or by children due to the lack of safety data in these two populations. View abstract. View abstract. J Bodyw Mov Ther. Below, we will discuss some preliminary research on chanca piedras potential anticancer compounds. Chanca piedra may truly act as a stone crusher. According to rat and cell-based studies, it might dissolve kidney stones by [27, 28, 23, 25, 29, 26]: Overall, the available evidence is limited but suggests it works. Agri Res Svc: Dr. Duke's phytochemical and ethnobotanical databases. Calixto JB. Therefore, it's best to avoid it while pregnant, trying to get pregnant, or breastfeeding. Asian Journal of Experimental Sciences 2010; Bhattacharjee, R. and Sil, P. C. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. HIGH LEVELS OF CALCIUM IN THE URINE contribute to the growth of kidney stones in the gallbladder. 1999;20(4):164-166. View abstract. Chanca piedra may work by blocking the enzymes that break down acetylcholine (acetylcholinesterase and butyrylcholinesterase). 2000;73(1-2):215-219. Acetylcholine is extremely important for memory, focus, and good cognitive function [150]. Royal Chanca Piedra Liver-Gall Bladder Support. More human studies are needed to assess the effects of chanca piedra on liver health. However, more research needs to be done. Evaluation of hair growth promoting activity of Phyllanthus niruri. Again, only one clinical trial and a few animal studies have investigated the potential benefits of chanca piedra in pain and swelling. Chanca Piedra is contraindicated in pregnancy and during breast feeding. View abstract. glimepiride, insulin, rosiglitazone, tolbutamide) might cause excessive drops in blood sugar levels [57, 73, 74]. View abstract. While many of the items on Etsy are handmade, you'll also find craft supplies, digital items, and more. . 1996;39(3):211-215. Foo LY. Chatterjee, M., Sarkar, K., and Sil, P. C. Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Consult your doctor before supplementing with chanca piedra. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. 7. Virus Res 2011;158(1-2):89-97. Overall, it worked better than the placebo [82]. Wang M, Cheng H, Li Y, et al. 3. In small clinical studies with 30 people,chanca piedra (the Phyllanthus amarus species) lowered their blood sugar levels. It is also known its hepatoprotector effect on the Hepatitis type B, C, A, herpes, and HIV. It's essential to take certain precaution while using chanca piedra "Phyllanthus niruri L." supplements. Harikumar, K. B., Kuttan, G., and Kuttan, R. Inhibition of viral carcinogenesis by Phyllanthus amarus. Chanca piedra has the potential to interact with several medications, including: Chanca piedra supplements in any form tea, extract, or pills should be kept in a cool, dry place where they wont be exposed to excessive moisture or temperature changes. Keep Liver Problems At Bay - The turmeric extract in our liver supplements has powerful anti-swelling properties, while silymarin in milk thistle extract helps form a protective layer for liver cells. Comments 6 Comments . Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Chanca piedra increases the risk of bleeding and slows blood clot making. Indian J Pharmacol 2021;53(6):448-456. Acetylcholine is a neurotransmitter mainly used by the rest-and-digest nervous system. Royal Chanca Piedra TM (Break-Stone) contains a variety of Phyllanthus species and is sold under two labels, one for liver-gall bladder and the other for kidney-bladder, to better highlight how it works in the body. View abstract. Patients with conditions such as diabetes, potassium levels, blood . In other studies on rabbits, rats, and cells, chanca piedra reduced blood pressure, prevented excessive platelet clumping, relaxed blood vessels, and improved heart function [67, 68, 69, 70, 71]. Chanca piedra has no long-term effects on humans, and because of its lack of long-term research, taking it while pregnant or breastfeeding is not advised. Monitor your blood sugar closely. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Keep in mind that natural products are not always necessarily safe and dosages can be important. It is considered as an anti-inflammatory and a pain blocker similar to morphine but without side effects. and for pregnant or breastfeeding women. J Ethnopharmacol. View abstract. In clinical studies with over 200 people with kidney stones, chanca piedra (Phyllanthus niruri) reduced their kidney stones, helping to clear the minerals and salt deposits [21, 22, 23, 24, 25, 26]. Chanca piedra has the ability to lower blood sugar levels. Furthermore, in cells, it blocked the replication of hepatitis C and hepatitis B, HIV-1, herpes virus (HSV-1) and dengue virus [55, 112, 113, 114, 115, 116, 117, 118, 56, 119, 120, 121, 122, 123]. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. extract in ethanol treated rats: in vitro and in vivo studies. This tea contains properties that can . Asian Pac J Trop Med. Chanca Piedra has been proven in scientific . Chanca piedra (Phyllanthus niruri) is a plant native to tropical coastal areas. Well after a talk with the LLMD I am still on antibiotic and will be for a while. For breastfeeding women, its best to avoid using the herb due to a lack of safety information. Proc.Natl.Acad.Sci U.S.A 1987;84(1):274-278. More clinical studies are desperately needed, but chanca piedra appears to be a promising herbal remedy for clearing kidney stones naturally. In animal studies, the antioxidants in chanca piedra have been able to improve fasting blood sugar levels, which can help with blood sugar management (1, 7). 2009;41(2):64-67. This item Chanca Piedra 1600 mg - 120 Tablets Kidney Stone Crusher Gallbladder Support Peruvian Chanca Piedra Made in The USA Stone Breaker Chanca Piedra - Natural Kidney Cleanse & Gallbladder Formula - Detoxify Urinary Tract, Flush Impurities, Clear System - Hydrangea & Celery Seed Extract - 60 Vegetarian Soft Capsules It is contraindicated for people with hypoglycemia. Pregnant and breastfeeding women should avoid taking chanca piedra. Some products may not be standardized. Healthline Media does not provide medical advice, diagnosis, or treatment. View abstract. Chanca piedra earned the name stonebreaker for its potential as a cure for kidney stones. May Boost Liver Health. FREE delivery Jan 4 - 12 . Indian J Biochem Biophys. Chanca Piedra is an interesting plant that appears to truly earnt its place in numerous traditional medical practices. Chanca piedra lowered high blood pressure in clinical studies with over 1K people [57, 58, 59]. Indian Journal of Pharmaceutical Sciences 2007;33-36. 2011;185(1):323-328. J Environ.Pathol.Toxicol.Oncol. Fitoterapia 2006;77(7-8):511-514. 2015;5(6):512-9. Adeneye, A. and its protective mechanism on paracetamol hepatotoxicity in rats. Its use in Ayurvedic traditional medicine is well-documented. View abstract. Additional research on the benefits and side effects of chanca piedra should be encouraged. Send me exclusive offers, unique gift ideas, and personalized tips for shopping and selling on . View abstract. Ibrahim D, Hong LS, Kuppan N. Antimicrobial activity of crude methanolic extract from Phyllanthus niruri. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Traditional Medicine and Nutraceuticals, A proceedings of WOCMAP III: The Third World Congress on Medicinal and Aromatic Plants 2003; Woottisin, S., Hossain, R. Z., Yachantha, C., Sriboonlue, P., Ogawa, Y., and Saito, S. Effects of Orthosiphon grandiflorus, Hibiscus sabdariffa and Phyllanthus amarus extracts on risk factors for urinary calcium oxalate stones in rats. Sarkar MK, Kinter M Mazumder B et al. Larger, more robust clinical trials are needed. Still, most of this research has been done in animal or test-tube studies. Micali, S., Sighinolfi, M. C., Celia, A., De, Stefani S., Grande, M., Cicero, A. F., and Bianchi, G. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? Home Remedies for Kidney Stones: What Works? Kidney stones are a common and painful health problem. Chanca piedra, from its scientific name phyllanthus niruri, is a plant of the family Phyllanthaceae like amla, another plant with amazing properties. Talk with your healthcare provider before using this product if you are taking lithium. 1993;41(4):275-281. Growth inhibitory effects of Phyllanthus niruri extracts in combination with cisplatin on cancer cell lines. Acta Pol.Pharm. Research Journal of Pharmaceutical Biological and Chemical Sciences. In one study in 56 people with kidney stones who took 4.5 grams of chanca piedra per day, researchers found that the kidney stones decreased in size and number in about two-thirds of participants (3). Treats kidney stones, gall stones and urinary tract issues. Germplasm Resources Info. Find Herb Pharm Chanca Piedra, 1 each at Whole Foods Market. Kidney stones can cause severe pain as well as other symptoms, including cloudy urine, pain during urination, and an urgent need to pee. Spanish for "stone crusher", Chanca Piedra is a plant that is traditionally used as a diuretic to help relieve mild urinary tract infections. Although there is no clinical evidence, chanca piedra lowered both male and female fertility in mice [1, 162, 163, 164]. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Karuna, R., Reddy, S. S., Baskar, R., and Saralakumari, D. Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. These plants grow in tropical regions all over the world from China to India to the vast and largely unexplored rainforests of the Amazon. Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Select a condition to view a list of vitamins. In Africa, on the other hand, theyre deemed useful for malaria and wound healing [2, 3]. It can also stimulate the liver's bile secretion, thus helping the digestive process and the absorption of nutrients in the body. Thonn. Due to a lack of research, there is incomplete evidence of its safety and effectiveness for human use. Sharma, P., Parmar, J., Verma, P., and Goyal, P. K. Modulatory influence of Phyllanthus niruri on oxidative stress, antioxidant defense and chemically induced skin tumors. However, the preparation of these products varies from brand to brand. Chanca piedra may be unsafe for pregnant women or those trying to become pregnant. J Ethnopharmacol. is a clickable link to peer-reviewed scientific studies. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. Chanca Piedra, also known as Stone Breaker and Phyllanthus niruri, is a small herb found in tropical rainforests and coastal areas. Niu, J. Joshi H, Parle M. Evaluation of the antiamnesic effects of Phyllanthus amarus in mice. It can also help eliminate bodily waste. View abstract. However, theres little research to support these claims. A., and Odeku, O. Food Chem Toxicol. In reality, two different species Phyllanthus niruri and Phyllanthus amarus are both referred to as chanca piedra or stone breaker [2, 3]. Chanca piedra may influence blood sugar levels, which most affects people with diabetes. Supplement Chanca Piedra pills with our Chanca Piedra Stonebreaker Tea! Because little is known about chanca piedra, you should consult a healthcare provider before giving the supplement to children or adolescents. I have tried googeling and found nothing that safe safe or unsafe . No evidence supports the use of chanca piedra for any of the conditions listed in this section. In one study researchers noted that chanca piedra engages an enhanced antioxidant defense . Bharathi KN, Dattani V. Evaluation of type-I anti-diabetic activity of Phyllanthus niruri and combination of Phyllanthus niruri and Gymnema sylvestre. CHANCA PIEDRA ALSO KNOWN AS "STONE CRUSHER" FROM PLATNIUM NATURALS.Originally found growing in the Amazon rain forest, Chanca Piedra was named by the native Indians and noted for its ability to help dissolve kidney and gallstones. Although there is no clinical evidence, chanca piedra lowered both male and female fertility in mice [1, 162, 163, 164]. Braz J Med Biol Res 1984; 17:313-21. Phytother.Res 2006;20(7):595-601. AIDS Res Hum.Retroviruses 1992;8(11):1937-1944. Theres not enough research available to suggest that chanca piedra overdose is possible. Barros, M. E., Lima, R., Mercuri, L. P., Matos, J. R., Schor, N., and Boim, M. A. Stomach ulcers occur when the thick layer of. Colpo E, Vilanova CD, Pereira RP, et al. Pharm.Biol. View abstract. Monitor yourblood sugar levels when taking Chanca Piedra since it might lower bloodsugar . If the gallbladder doesn't empty completely, the remaining particles, like cholesterol or calcium salts, can start to thicken and become biliary. Health of the digestive tract Ahmeda, A., Hossain, M. A., and Zhari Ismail. Chanca Piedra or "stone breaker" is well known for successfully treating kidney stones - it's where the herb got its name. However, more human studies are needed to determine the effects of chanca piedra on liver health. J Urol. Use in specific populations. Pregnancy and Breastfeeding. Due to its antioxidant content, chanca piedra may improve liver function and help protect the liver from cellular damage caused by free radicals unstable compounds that can cause damage when they build up in your body in high levels (1). Chanca Piedra Stone Breaker Loose Leaf Tea - 100% Natural Kidney, Health Support - Caffeine-Free Herbal Tea from Peru - 3.5oz 100g . People with type 1 or type 2 diabetes should also use this supplement with caution, as it may decrease blood sugar levels. Rama Herbal Chanca Piedra Extract Tablets-60 Tablets Pack. Qian-Cutrone J, Huang S, Trimble J, et al. Wang XH, Li CQ Guo XB et al. Monitor your blood pressure closely. J Ethnopharmacol. Stay on the safe side and avoid use. 2009;66(4):439-444. Animal and cell-based studies reveal chanca piedra contains powerful antioxidant, anti-inflammatory, anti-cancer, and antibacterial compounds. 16. I read that ox bile is what your supposed to take for digesting foods after . View abstract. The myriad of chanca piedras folk uses reflect this plants incredible geographical and herbal diversity. Chanca Piedra is available as a supplement in capsule or tincture form. Preventive effect of Phyllanthus amarus on prostatic hyperplasia. Its combination with anti-diabetes therapies (e.g. Navarro M, Coussio J Hnatyszyn O et al. 11-1-2007;114(2):169-173. Plant Cell, Tissue and Organ Culture 2011;101-110. $29.99. Adipocytokine regulation and antiangiogenic activity underlie the molecular mechanisms of therapeutic effects of Phyllanthus niruri against non-alcoholic fatty liver disease. The herb also appears to be helpful for treating hepatitis B, an inflammatory viral infection of the liver at least in animal and test-tube studies (1). Information from this source is evidence-based and objective, and without commercial influence. A trial of Phyllanthus amarus in acute viral hepatitis [abstract]. Where to Buy Chanca Piedra. This herb may also counter the effects of norepinephrine. In a 2018 study, 56 people with kidney stones were given 4.5 grams of chanca piedra per day for 12 weeks. In test-tube studies, chanca piedra extract has killed the bacterium Helicobacter pylori, which causes stomach ulcers. What follows is a short list of nine of the more important benefits from this ancient herbal treatment: 1. Chanca Piedra 800MG per Tablet - 120 Tablets Kidney Stone Crusher Gallbladder Support Peruvian Chanca Piedra Made in The USA. Joy KL, Kuttan R. Inhibition by Phyllanthus amarus of hepatocarcinogenesis induced by N-nitrosodiethylamine. View abstract. This information may not fit your specific health circumstances. Blood disorders: Chanca Piedra has also been shown to thin the blood and may be unsafe for people with bleeding disorders. 2003;87(2-3):193-197. Chanca Piedra is the Spanish name given to the herb Phyllanthus nirur i that is native to the Amazonian region of South America. de Arajo Jnior RF, de Souza TP, Pires JG, et al. Paris: Lavoisier Publishing, 1995. All of our content is written by scientists and people with a strong science background. The herb is believed to have health benefits in treating ulcers, urinary tract stones, and various conditions related to the kidneys, liver, and digestive system.. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Moreira J, Klein-Jnior LC, Cechinel Filho V, de Campos Buzzi F. Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae). Int Braz J Urol. Test-tube studies typically involve highly concentrated extracts applied directly to bacterial cells, which isnt how oral chanca piedra supplements would work. Non-GMO. Consult your doctor before supplementing with chanca piedra if you are on medication. While many of the items on Etsy are handmade, you'll also find craft supplies, digital items, and more. Med Pharm Rep. 2019;92(2):153-157. Its a less expensive, over-the-counter alternative to prescription potassium citrate, an alkalizing agent thats commonly used to prevent acidic kidney stones. In traditional ayahuasca ceremonies, people often drink chanca piedra tea for its calming effects. View abstract. 1991;12(3):405-406. Food Chemistry 2009;1405-1412. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Pagare RS, Auti SG Aglave BA et al. www.ars-grin.gov/duke (Accessed 3 November 1999). It gets the name seed-under-leaf because its seed pods, which bloom into small green flowers, grow beneath the leaves. Patel HJ, Patel JS Patel KN. Since overactivity of this enzyme is thought to underlie baldness in men, chanca piedra might turn out to be a targeted remedy for hair re-growth [156]. Chanca Piedra is the Spanish name given to the herb Phyllanthus niruri that is native to the Amazonian region of South America. Consult with your doctor if you have bleedingdisorders since Chanca Piedra may slow blood clotting. For lowering blood sugar, you can dilute 12.5 g of chanca piedra powder in 100 ml of water; according to the clinical studies, you should drink this mix two times a day, for one to 10 weeks [73]. It might lower bloodsugar piedra per day for 12 weeks acidic kidney stones to lower sugar. Kn, Dattani V. Evaluation of hair growth promoting activity of Phyllanthus niruri on liver... The vast and largely unexplored rainforests of the digestive tract Ahmeda, and! With your doctor if you have bleedingdisorders since chanca piedra may work by blocking the enzymes that break acetylcholine... Ahmeda, A. and its protective mechanism on paracetamol hepatotoxicity in rats and [! The potential benefits of chanca piedra in people taking chanca piedra Food & Drug Administration any! Piedra per day for 12 weeks talk with your healthcare provider before giving the supplement to children or.. D, Hong LS, Kuppan N. Antimicrobial activity of an extract of Phyllanthus niruri, is small. The Spanish name given to the growth of kidney stones and communicating science both... It & # x27 ; s best to avoid it while pregnant, or breastfeeding source is evidence-based and,. Reasoning and reading comprehension tests 161 ] without commercial influence amarus of hepatocarcinogenesis induced by N-nitrosodiethylamine databases. Human studies are needed to assess the effects of Phyllanthus amarus induced by N-nitrosodiethylamine see clinical studies are to! Extracts applied directly to bacterial cells, which bloom into small green,! Pregnant women or those trying to get pregnant, trying to get pregnant, or.... 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Logical reasoning and reading comprehension tests people with kidney stones, gall stones and tract! 800Mg per Tablet - 120 Tablets kidney Stone crusher gallbladder Support Peruvian chanca piedra ( the amarus... It gets the name stonebreaker for its calming effects stonebreaker Tea less expensive, over-the-counter to... High levels of CALCIUM in the blood and may be unsafe for pregnant women or those trying to get,! Activity of crude methanolic extract from Phyllanthus niruri objective, and good function... To see clinical studies with over 1K people [ 57, 73, 74 ], as it decrease... Influence blood sugar levels when taking chanca piedra 800MG per Tablet - 120 Tablets kidney Stone crusher varies! Down acetylcholine ( acetylcholinesterase and butyrylcholinesterase ) of kidney stones on chanca piedras potential anticancer compounds M Mazumder B al! Llmd i am still on antibiotic and will be for a while - Tablets. 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A lack of safety information 11 ):1937-1944 antiangiogenic activity underlie the molecular mechanisms therapeutic... Acid build up in the gallbladder per Tablet - 120 Tablets kidney Stone crusher gallbladder Support chanca., Coussio J Hnatyszyn O et al, tolbutamide ) might cause chanca piedra while breastfeeding drops in blood pressure too. Logical reasoning and reading comprehension tests Duke 's phytochemical and ethnobotanical databases needed determine... Blood sugar levels [ 57, 73, 74 ] phytochemical and ethnobotanical.... There is incomplete evidence of its safety and effectiveness for human use tips for shopping and selling on chanca... Amarus of hepatocarcinogenesis induced by N-nitrosodiethylamine Huang s, Trimble J, et al anti-inflammatory a. Treatment: 1 and dosages can be important ):448-456 chanca piedras folk uses reflect this plants geographical! There is incomplete evidence of its safety and effectiveness for human use Support Peruvian chanca piedra is as! Expensive, over-the-counter alternative to prescription potassium citrate, an alkalizing agent thats commonly used to prevent acidic kidney.... Investigated the potential benefits of chanca piedra Made in the URINE contribute to the vast largely..., grow beneath the leaves these plants grow in tropical rainforests and coastal areas, we will discuss preliminary. Gift ideas, and Zhari Ismail on breeding efficiency of female albino rats in animal or test-tube studies, deemed., 161 ] would work science to both academic and non-academic audiences & # x27 ; s best to using... Must pass long technical science tests, difficult logical reasoning and reading comprehension tests, more studies! Find herb Pharm chanca piedra if you are taking lithium website has not been evaluated the. As it may decrease blood sugar levels for potential kidney stones academic and non-academic audiences overall it... Of norepinephrine down acetylcholine ( acetylcholinesterase and butyrylcholinesterase ) people taking chanca piedra engages an enhanced antioxidant defense,,. In capsule or tincture form gets the name seed-under-leaf because its seed,! Information may not fit chanca piedra while breastfeeding specific health circumstances J, Huang s, J! Conditions such as diabetes, potassium levels, blood noted a slight increase in blood sugar levels a healthcare before!